The CB1 receptor is activated by cannabinoids, generated naturally inside the body (endocannabinoids) or exogenously, normally through cannabis or a related synthetic compound. Research suggests that …

The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, …

Jul 23, 2025 · CB1 receptors are specialized proteins found on the surface of cells throughout the human body. They function as receiving antennas, interacting with chemical signals that help …

Mar 5, 2025 · Researchers have been interested in targeting the CB1 receptor – so named because it is a binding site for the tetrahydrocannabinol (THC) molecules in cannabis – to treat chronic pain for …

The high-resolution cryo-EM structure of CB1-β-arrestin1 complex offers insights into the distinction of agonists in various transducer-coupled states and reveals the molecular mechanism of the biased …

Sep 1, 2017 · CB 1 receptors are present at both presynaptic terminals and postsynaptic compartments of neurons and on astrocytes, exerting different impacts at the tripartite synapse.

Jul 4, 2025 · CB1 receptors are one of two primary types of cannabinoid receptors found in the human body’s endocannabinoid system (ECS) — a biological system that helps regulate balance and …

CB1 receptors are defined as 7-transmembrane receptors that mediate psychoactive responses to cannabis extracts and are among the most abundant receptors in the central nervous system.

Jul 26, 2025 · The CB1 receptor is a G protein-coupled receptor found extensively throughout the body, with its highest concentration in the central nervous system, particularly in the brain and spinal cord.

Cannabinoid receptor type 1 (CB 1) receptors are thought to be one of the most widely expressed G αi protein-coupled receptors in the brain.