CARLISLE COUNTY, Ky. (KFVS) - A portion of U.S. 51 is blocked by a crash in Carlisle County on Monday afternoon, August 25.

The first human case of the flesh-eating parasite, New World Screwworm, has been detected in the United States.

CAPE GIRARDEAU, Mo. (KFVS) - Cape Girardeau Police are investigating a deadly two-vehicle crash on Saturday, August 23. It ...

SCOTT CITY, Mo. (KFVS) - Emergency crews are on the scene of an accident at a quarry in Scott City. According to Scott City ...

According to Caruthersville Police, 45-year-old Tiffany N. Rittenberry, a former secretary/treasurer of Sacred Heart Catholic ...

The current rules allow flyers to buy an extra seat ahead of time and get refunded later, or request an extra seat at no ...

One driver was killed and another driver was seriously injured in a two-vehicle crash in Poplar Bluff.

(CNN) - The Powerball jackpot has jumped to a staggering $750 million, which is the 10th largest in the game’s history. No ...

MOUNT VERNON, Ill. (KFVS) - A Mount Vernon man was arrested in connection with a shooting investigation. Officers were called ...

A beautiful fall-like pattern looks to stick around for the next few days! Some high and mid clouds, along with a northeast ...

Students in Mayfield Independent Schools will return to class on Monday, and school leaders are offering trauma support for ...

Drivers should look out for some changes on Route 13 between Spillway Road and Greenbriar Road near Carterville, Ill.