Excessive proliferation of vascular smooth muscle cells (VSMCs) is a consequence of type 2 diabetes (T2D) that increases the risk for atherosclerosis and restenosis after angioplasty. Here, we sought ...

Platelet activation relies on changes in cytoplasmic calcium flux. However, little is known about the role mitochondrial calcium flux plays in platelet activation. Activation induces release of ...

This mitochondrial process supports the brain cells essential to learning, memory and social recognition. We know that mitochondria are the powerhouses of the cell, but what role do they play in ...

Lung cancer remains a significant global health challenge and identifying lung cancer at an early stage is essential for enhancing patient outcomes. The study focuses on developing and optimizing gene ...

name: uniporter activity def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ...

Calcium enters mitochondria via calcium uniporter and regulates cellular energy production and survival. The uniporter activity is tightly regulated by calcium that changes the channel functioning ...

Mitochondrial Ca 2+ uniporter (MCU) has been recently reported to be involved in activation of the NLRP3 inflammasome due to mitochondrial damage. However, whether MCU is a general regulator of NLRP3 ...

For the first time, using a mouse model of Alzheimer's disease, scientists have documented a link between raised levels of calcium in mitochondria and neuronal death in the living brain. For the first ...

Like an emergency response team that is called into action to save lives, stress response proteins in the heart are activated during a heart attack to help prevent cell death. As part of this process, ...

The Unipiper – the Rose City’s unicycle-riding, bagpipe-playing embodiment of the “Keep Portland Weird” ethos – come this summer will add another feather to his Darth Vader cap: grand marshal of the ...