The Northwestern Wildcats and Washington Huskies are set to ignite their Big 10 Conference season with their first conference game this weekend in Seattle, Washington. This game marks a significant milestone for the Huskies as it’s their first-ever Big 10 game after leaving the Pac-12 in the offseason.

Analyzing Saturday’s Northwestern at Washington odds and lines, with college football expert picks, predictions and best bets.

Northwestern Wildcats vs Washington Huskies picks, predictions, odds, TV channel, streaming for Week 4 college football game on Saturday, Sept. 21.

This is a non-conference meeting between the two programs. Duke is 1-0 this season. They opened the 2024 campaign with a 26-3 win over Elon. The Blue Devils (8-5 in 2023) capped last season with a 17-10 win over Troy in the 76 Birmingham Bowl.

Washington 28, Northwestern 13. The Wildcats defense has been elite through three weeks, but the Huskies bring a completely different test. Washington QB Will Rogers ha