BMJ

FRI0016 R835, A NOVEL IRAK1/4 DUAL INHIBITOR IN CLINICAL DEVELOPMENT, BLOCKS TOLL-LIKE RECEPTOR 4 (TLR4) SIGNALING IN HUMAN AND MOUSE

Background: Toll-Like Receptors (TLR) and Interleukin-1 Receptors (IL-1R) play a critical role in the innate immune response as microbial sensors, providing a bridge between the innate and adaptive ...
BMJ

Plasminogen activation in synovial tissues: differences between normal, osteoarthritis, and rheumatoid arthritis joints

a Centre Hospitalier Universitaire Vaudois, Laboratoire de Rhumatologie, Lausanne, Switzerland , b Centre Medical Universitaire, Division d’Oncologie, Geneva, Switzerland Dr N Busso, Centre ...
BMJ

All-cause, cause-specific and age-specific standardised mortality ratios of patients with systemic lupus erythematosus in Ontario, Canada over 43 years (1971–2013)

Correspondence to Dr Murray Urowitz, Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Lupus Clinic, Toronto, ON M5T2S8, Canada; ...
BMJ

Physiotherapy for anterior knee pain: a randomised controlled trial

OBJECTIVE To determine the efficacy of the individual components of physiotherapy in subjects with anterior knee pain. METHODS An observer blind, prospective, factorial design randomised controlled ...
BMJ

Temporary hold of mycophenolate augments humoral response to SARS-CoV-2 vaccination in patients with rheumatic and musculoskeletal diseases: a case series

Mycophenolate is the mainstay of treatment for many organ and life-threatening manifestations of rheumatic and musculoskeletal diseases (RMD). In contrast to most patients with RMD, those taking ...
BMJ

Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles

1 Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands 2 Departments of Rheumatology and Epidemiology, Leiden University Medical Centre 3 Department of Immunohaematology ...
BMJ

2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative

41 St. Joseph's Health Care London and University of Western Ontario, London, Ontario, Canada Objective The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis ...
BMJ

European Scleroderma Study Group to define disease activity criteria for systemic sclerosis. III. Assessment of the construct validity of the preliminary activity criteria

Objective: To further assess the construct validity of the three European Scleroderma Study Group (EScSG) preliminary activity indices for systemic sclerosis (SSc): for SSc as a whole, for diffuse SSc ...
BMJ

The fatty Romanus lesion: a non-inflammatory spinal MRI lesion specific for axial spondyloarthropathy

Background Fatty changes at vertebral corners have been reported on MRI in ankylosing spondylitis but the distribution or specificity of these lesions to early axial spondyloarthropathy (axial-SpA) ...
BMJ

Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile ...

Objectives Interferon-γ (IFNγ) is the pivotal mediator in murine models of primary haemophagocytic lymphohistiocytosis (pHLH). Given the similarities between primary and secondary HLH (sec-HLH), ...
BMJ

The global burden of occupationally related low back pain: estimates from the Global Burden of Disease 2010 study

1 Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia 2 School of Public Health and Community Medicine, University of New South Wales, Sydney, New South Wales, ...
BMJ

Anti-CD20 monoclonal antibody (rituximab) as an adjunct in the treatment of giant cell arteritis

1 Department of Rheumatology, University College London Hospitals, Arthur Stanley House, 40-50 Tottenham Street, London W1T 4NJ, UK 2 Institute of Nuclear Medicine, University College London Hospitals ...