Not long after nearly losing a fumble on a sack, Mac Jones finally unravels for the 49ers, tossing a deep pick to Jamel Dean that just might seal a home victory for Tampa Bay, which is getting heroic stuff from its own gunslinger in Baker Mayfield:

The San Francisco 49ers travel to Florida to face the Tampa Bay Buccaneers for NFL Week 6, and there are several ways to watch and stream the football game scheduled at 4:25 p.m. ET / 1:25 p.m. PT.

The Buccaneers improve to 5-1 with a 30-19 win against the 49ers, as coach Bowles discusses strategies and key players standout.

Find out how to watch the NFL Week 6 game between the Tampa Bay Buccaneers and San Francisco 49ers, as well as the latest odds and updated injury

The 49ers vs. Buccaneers game kicks off at 4:25 p.m. ET/1:25 p.m. PT on Sunday, Oct. 12, 2025. The Week 6 game between the 49ers and the Buccaneers will air in select markets on CBS, which means it'll also stream live in those markets on Paramount+. You can also tune in on mobile devices with NFL+.

The injury report for the Tampa Bay Buccaneers (4-1) heading into their game against the San Francisco 49ers (4-1) features 11 players. The contest starts at 4:25 p.m. ET on Sunday, Oct. 12, at Raymond James Stadium. Game time: 4:25 p.m. ET

An NFL executive was gushing about the way Baker Mayfield has been playing for the Tampa Bay Buccaneers to The Athletic.

The Tampa Bay Buccaneers shared some concerning injury updates on wide receiver Chris Godwin and running back Bucky Irving.