The process of DNA replication relies on the coordinated action of a ring‐shaped sliding clamp and its specialised loader complexes. Sliding clamps, typified by proliferating cell nuclear antigen ...
Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...
Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the ...
Researchers in the lab of John Kuriyan, professor of biochemistry and dean of the School of Medicine Basic Sciences, have revealed a key element of how a molecular machine responsible for high-speed ...
The DNA damage response is essential for maintaining genome integrity. When DNA damage or replication stress occurs, a checkpoint signaling pathway is activated to arrest the cell cycle and initiate ...
The clamp then closes and signals to the polymerases that they can begin replicating DNA. Using high-powered cryo-electron microscopes, Li, O'Donnell and their teams revealed previously unknown facets ...
The clamp then closes and signals to the polymerases that they can begin replicating DNA. Using high-powered cryo-electron microscopes, Li, O'Donnell and their teams revealed previously unknown facets ...
DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...
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