The betting market clearly respects Louisville’s perfect record, making the Cardinals 3.5-point road favorites. The money line reflects that confidence, with Louisville sitting at -169 while Arkansas checks in as a +140 home underdog. That massive 165.5-point total suggests the books expect fireworks in this one.

LOUISVILLE, Ky. - After a few extra days off, game day for the Louisville men's basketball is back, and they have no shortage of storylines for their next matchup. The Cardinals are now set for their first true road game of the 2025-26 season, taking on John Calipari, Kenny Payne and the Arkansas Razorbacks in the annual ACC/SEC Challenge.

The No. 6 Louisville Cardinals tip off against the No. 23 Arkansas Razorbacks at 7:15 p.m. ET Wednesday at Bud Walton Arena in Fayetteville, Arkansas.

Louisville head coach Pat Kelsey was agitated with the Cardinals after their Wednesday night loss to Arkansas.

From the jump, Louisville seemed to struggle with Arkansas' length and athleticism, and even seemed to be rattled a bit. The Razorbacks scored the first six points of the game, and thanks to 14 points from Brazile in the first eight minutes, took a 23-17 lead over the first nine-plus minutes.