What's the San Francisco 49ers vs Arizona Cardinals score? Follow our live updates for latest news, highlights, analysis from NFL Week 18 game.

Despite entering their season finale on Sunday having lost five of their previous six games, the Arizona Cardinals had a chance to double their win total from a year ago. From the outset, that would have been enough to call this a successful season.

Player prop betting options will be available for Kyler Murray ahead of Sunday’s NFL action at 4:25 PM ET live on FOX. NFC West rivals meet in Week 18 when Murray’s Arizona Cardinals

San Francisco (6-10) rides a three-game losing streak into a matchup with (-) on Sunday, January 5, 2025 at State Farm Stadium. The Cardinals are listed as favorites in this one, with the spread

Arizona Cardinals' linebacker Zaven Collins hits San Francisco 49ers quarterback Josh Dobbs who sees a pass go backwards for a 16-yard loss. Arizona Cardinals' quarterback Kyler Murray finds wide receiver Marvin Harrison Jr. for a 14-yard gain.

The Cardinals delivered the dominant offensive performance fans have been craving against the San Francisco 49ers.

Kyler Murray was the No. 1 overall pick in the 2019 draft. He was charged with turning around a franchise that hasn’t won an NFL championship since 1947.

Kyler Murray threw for 242 yards and four touchdowns, two to Greg Dortch, and the Arizona Cardinals beat the injury-depleted San Francisco 49ers 47-24.