BMJ

The EQ-5D—a generic quality of life measure—is a useful instrument to measure quality of life in patients with Parkinson's disease

OBJECTIVE To test the feasibility and validity of the EQ-5D (a widely used generic (disease non-specific) quality of life (QoL) instrument which allows comparisons between different patient groups and ...
BMJ

Autonomic dysfunction in dementia

Background: There are no studies of autonomic function comparing Alzheimer’s disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). Aims: To ...
BMJ

Personalised dual-site alpha transcranial alternating current stimulation (tACS) targeting right frontoparietal network reduces craving in heroin use disorder

The opioid crisis is a significant public health issue that has led to a rising number of overdose deaths over the past 25 years. Cue-induced drug craving leads to a high risk of relapse, which urged ...
BMJ

The prevalence and causes of dementia in people under the age of 65 years

Objectives: To determine the prevalence of dementia in people under the age of 65 in a large catchment area, and use these figures to estimate the number of younger people affected by dementia in the ...
BMJ

Mitochondrial disease associated with the T8993G mutation of the mitochondrial ATPase 6 gene: a clinical, biochemical, and molecular study in six families

Dr Massimo Zeviani, Division of Biochemistry and Genetics, Istituto Nazionale Neurologico “Carlo Besta”, Via Celoria 11, Milano 20133, Italy. AIM To contribute to the establishment of a rational ...
BMJ

Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis

Background Staging of disease severity is useful for prognosis, decision-making and resource planning. However, no commonly used, validated staging system exists for amyotrophic lateral sclerosis (ALS ...
BMJ

Evolution of brain MRI lesions in paediatric myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and its relevance to disease course

Background Lesion resolution is often observed in children with myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and asymptomatic lesions are less commonly reported in MOGAD ...
BMJ

Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

Correspondence to Dr Zhang-Yu Zou, Department of Neurology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China; pumczzy{at}gmail.com or ...
BMJ

Survival in memory clinic cohort is short, even in young-onset dementia

Correspondence to Hanneke Frederica Maria Rhodius-Meester, Alzheimer Center, VU University Medical Center, Amsterdam 1007 MB, The Netherlands; h.rhodius{at}vumc.nl Patients with dementia have a ...
BMJ

Stunned brain syndrome: serial diffusion perfusion MRI of delayed recovery following revascularisation for acute ischaemic stroke

Background Clinical response immediately after revascularisation therapy differs among patients. Although reperfusion is the deciding factor with respect to this dramatic response to revascularisation ...
BMJ

VIRAL ENCEPHALITIS: CAUSES, DIFFERENTIAL DIAGNOSIS, AND MANAGEMENT

Correspondence to: Professor P G E Kennedy Department of Neurology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK; p.g.kennedyclinmed.gla.ac ...
BMJ

Recommended diagnostic criteria for paraneoplastic neurological syndromes

Background: Paraneoplastic neurological syndromes (PNS) are defined by the presence of cancer and exclusion of other known causes of the neurological symptoms, but this criterion does not separate ...