The BA transporter OSTα/β has a crucial role in maintaining BA homeostasis and lipid metabolism 5,6,9,10. BAs are synthesized from cholesterol in the liver and serve as key regulators for the ...

Retrons are prokaryotic reverse transcriptase systems that produce multicopy single-stranded DNA (msDNA), yet the principles by which they mediate antiviral defense remain largely unresolved. Here we ...

Scientists at St. Jude Children's Research Hospital have used cryo-electron microscopy to generate ten structures of URAT1, a protein linked to gout. Gout is a type of arthritis caused by excess urate ...

When speaking of motors, most people think of those powering vehicles and human machinery. However, biological motors have existed for millions of years in microorganisms. Among these, many bacterial ...

This study systematically elucidates the multifunctional transport properties and structural basis of BTR1, a member of the SLC4 family. Using cryo-electron microscopy (cryo-EM) and electrophysiology, ...