The replication control system of plasmid R6-5 has been investigated by characterization of high-copy-number mutant miniplasmids, development of an in vivo assay for the site of action or ``target'' ...
Non-viral gene therapy has the potential to be a promising therapeutic intervention for various diseases due to its low toxicity and safety concerns. However, to make this a reality, gene transfer ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 15 (Jul. 22, 2003), pp. 8692-8697 (6 pages) The DnaA replication initiation protein has been shown to be ...
Advanced engineering of a mini-intronic plasmid (MIP) system designed to carry a therapeutic gene can significantly enhance the expression of the transgene delivered using an adeno-associated viral ...
FARGO, N.D.--(BUSINESS WIRE)--Aldevron, the world’s leading contract plasmid manufacturing organization, has announced the immediate availability of an off-the-shelf version of pXX6-80, a common adeno ...
Plasmid DNA lies at the heart of viral and mRNA vector production because it provides the coding sequences for gene-based advanced therapy medicinal products (ATMPs). Its manufacture is therefore ...
Plasmids are essential for the development of viral vectors used to manufacture novel gene therapies and viral vaccines. Aldevron is supporting the innovation of drug developers in this space by ...
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