Nature

A comparison of molecular and cytogenetic techniques for the diagnosis of pregnancy loss

Purpose: To evaluate the sensitivity, specificity, advantages, and limitations of multiplex ligation-dependent probe amplification compared with conventional karyotype analysis in the investigation of ...
Nature

Computer-assisted prenatal aneuploidy screening for chromosome 13, 18, 21, X and Y based on multiplex ligation-dependent probe amplification (MLPA)

From mid-March to mid-November 2003, 1614 amniotic and chorionic villus samples (CVS) were referred to the Cytogenetic Laboratory for karyotyping and MLPA aneuploidy screening. Eight samples were ...
Science Daily

Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy

Researchers in the Netherlands believe they are on the verge of developing a simple, prenatal blood test that would be able to detect accurately chromosomal abnormalities in the developing fetus. At ...
GEN

Existing Technique Can Detect Fetal Genetic Abnormalities in Maternal Blood

Team found that MLPA assay can identify fetal DNA without invasive sampling. Netherlands-based researchers suggest that a technique currently used to detect fetal chromosomal abnormalities in maternal ...
Labroots

Multiplex Ligation-dependent Probe Amplification (MLPA)

Multiplex ligation-dependent probe amplification (MLPA) is a technique to detect copy number changes using polymerase chain reaction . This requires only 20 ng of sample DNA and can distinguish ...