Everything you need to know about the MLB matchup between the Houston Astros and the Seattle Mariners, including how to watch and team news.

The Seattle Mariners face the Houston Astros in a regular season MLB game on Sunday, Sept. 21, 2025 (9/21/25) at Daikin Park in Houston, Texas.

Suárez, a 34-year-old trade-deadline acquisition in his second stint with the Mariners, launched a go-ahead grand slam in Game 5 of the ALCS on Friday, lifting the Seattle Mariners to a 6-2 win over the Toronto Blue Jays and a 3-2 advantage in the series.

Back on the West Coast, it was pandemonium. T-Mobile Park erupted when Jorge Polanco laced a walk-off single to right field, sending the Mariners to the ALCS for the first time since 2001 and handing the Tigers an absolutely crushing, season-ending defeat.

Derek Jeter, Alex Rodriguez and David Ortiz reacted to the Los Angeles Dodgers' 5-1 win over the Toronto Blue Jays in Game 2 of the World Series. They also discussed the historic performance of Dodgers' pitcher Yoshinobu Yamamoto and previewed Game 3.