In recent years, it has become evident that the spatial organisation of the genome is key for its function. This depends on a number of factors, including the cohesin protein complex. This essential ...

Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires ...

Temporarily disabling a protein complex that organizes DNA into loops inside the cell's nucleus drastically disrupted the three-dimensional structure of the genome, but surprisingly most genes ...

They have already shown that a protein complex called NIPBL-MAU2 is essential for cohesin's motor function, and not just for loading cohesin onto DNA, as was previously believed. "We can now use our ...

Stem cells have great applications in regenerative medicine. While transcription factors traditionally dominate fate determination research, recent 3D genomics reveals chromatin topology’s critical ...

Twenty years ago, the protein complex cohesin was first described by researchers. They found that its shape strikingly corresponds to its function: when a cell divides, the ring-shaped structure of ...

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA and creates specific loops in the genetic material which determine the ...

A research team at Kyoto University has discovered STAG3-cohesin, a new mitotic cohesin complex that helps establish the unique DNA architecture of spermatogonial stem cells (SSCs), the stem cells ...

A cohesin molecule ensures the proper distribution of DNA during cell division. Scientists can now demonstrate the concept of its carabiner-like function by visualizing for the first time the open ...

Best known for its ability to regulate the separation of sister chromatids during cell division, the cohesin protein complex, a ring-shaped structure, has shown that it has other powers, such as the ...