It's unclear who the immediate starter is over Mixon, so the Rams will likely see some combination of Dameon Pierce, Dare Ogunbowale, ex-Cleveland Browns running back Nick Chubb and fourth-round rookie Woody Marks. Chubb is listed as the team's second running back, but all four players have seen action in training camp and in the preseason.

In the meantime, the Texans have four-time Pro Bowler Nick Chubb replacing Mixon in the starting lineup. Yet, the 29-year-old has battled injuries each of the past two seasons, playing in just 10 games. Plus, he hasn’t had a 1,000-yard season since 2022.