Top suggestions for Three canonical signals drive TH 1 cell differentiation: TCR (TCR CD3, signal 1), co-stimulation (CD28, signal 2) and cytokine signal ing (IL-12, signal 3). IL-12 binds to the IL-12R heterodimer, leading to downstream signaling and phosphorylation of STAT4 (refs. 26,27), which, together with T-bet, drives chromatin rearrangement, activa tion of a TH 1 cell gene program and expression of IFNγ.Explore more searches like Three canonical signals drive TH 1 cell differentiation: TCR (TCR CD3, signal 1), co-stimulation (CD28, signal 2) and cytokine signal ing (IL-12, signal 3). IL-12 binds to the IL-12R heterodimer, leading to downstream signaling and phosphorylation of STAT4 (refs. 26,27), which, together with T-bet, drives chromatin rearrangement, activa tion of a TH 1 cell gene program and expression of IFNγ. |
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